Yusuf played for 90 minutes while Chidera Ejuke was brought on in the 77th minute.
Antwerp broke the deadlock thanks to Yusuf, who scored in the 37th minute.
It is his first goal in all competitions for Antwerp this season.
But a hat-trick from Evanilson and a solitary strike from Stephen Eustaquio gave Porto the win.
Antwerp are bottom in the group with no point after three games played while Porto occupy second spot on six points.
In Group F AC Milan, without the injured Samuel Chukwueze lost 3-0 away to Paris Saint-Germain at the Parc Des Prince.
Milan are yet to record a win after three games and are bottom in the group with just two points.
The win took PSG to top in the group on six points from three games played.
Other results saw Manchester City beat Young Boys 1-0 away, Barcelona beat Shakhtar Donetsk 2-1, Red Star Belgrade lost 3-1 at Leipzig, Dortmund pipped Newcastle United 1-0 at St. James, Celtic and Atletico Madrid played 2-2 and Feyenoord defeated Lazio 3-1.
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