It is now back-to-back draws for Milan following their goalless draw against Newcastle at the San Siro.
Chukwueze replaced Christian Pulisic in the 69th minute but could not get on the score sheet.
Milan are third on two points after two round of games played.
In Belgium, Chidera Ejuke was an unused substitute while Alhassan Yusuf featured for Royal Antwerp who lost 3-2 at home against Shakhtar Donetsk.
Yusuf was introduced with seven minutes left to play as Royal Antwerp sufferer their second loss in the group.
The result of the night was at St. James Park with Newcastle United thrashing Paris Saint-Germain 4-1 in Group F.
It is now four points in two games for the Magpies in this seasons competition as they top the group on four points.
Other results saw champions Manchester City defeat RB Leipzig 3-1 away, Celtic lost 2-1 at home to Lazio, Atletico Madrid beat Feyenoord 3-2, Barcelona pipped FC Porto 1-0 and Red Star Belgrade was held to a 2-2 draw by Young Boys.